We are currently offering postdoctoral researcher and visiting PhD student positions in our research group. These positions are supported by newly funded grants from the NIH, non-federal research grants, and the Harry Fields endowment. The NIH grants supporting postdoc positions will commence this fall. Additionally, our translational research projects benefit from industry-sponsored research funds provided by leading pharmaceutical companies.
Over the past twenty-five years, our research has developed a novel computational approach that integrates large-scale genomic, functionomic, and pharmacologic profiles to identify key driver events in tumorigenesis. This innovative methodology led to the creation of the Functional Cancer Genome data portal (FCG, ), a pivotal resource for functionally annotating cancer genomes. Newly funded NIH projects will expand upon the transformative findings from FCG, focusing on in-depth experimental characterization of novel epigenetic and immuno-oncology drivers in cancer at the molecular mechanistic level, with the potential to advance cancer treatment.
We are currently recruiting for three related but independent projects: 1) Epigenetic dysregulation and non-coding RNAs in tumorigenesis, 2) Tumor immunology and immune therapy, and 3) Targeted and epigenetic therapy for cancer treatment. Candidates will be assigned to one of these projects based on their research background and personal interests. Our lab utilizes cutting-edge technologies including single-cell and spatial RNA sequencing analysis, CRISPR screen, and high-throughput chemical screening, all fully established in the PI’s lab. Additionally, our computational biology team offers a range of innovative computational approaches and resources to support these research endeavors.
We are actively seeking candidates with a strong background in cellular and molecular biology, epigenetics, RNA biology, or cancer immunology. Specifically, we are interested in individuals who have expertise in experimental technologies relevant to the molecular mechanisms of tumorigenesis. Previous experience in molecular biology, CRISPR screening, single-cell RNA sequencing, and tumor immunology would be highly advantageous. While these areas of expertise are preferred, we also encourage candidates from other fields to apply, including epigenetics, non-coding RNAs, and medicinal chemistry. We value diverse perspectives and interdisciplinary collaboration, believing that individuals from various scientific backgrounds can significantly contribute to our research endeavors. Joining our research group offers an exceptional opportunity to contribute to groundbreaking cancer research. You will collaborate with a dynamic, multidisciplinary team of scientists passionate about advancing the field. We eagerly anticipate welcoming individuals enthusiastic about making a difference in cancer research and thriving in a collaborative environment.
References for project 1 (epigenetics and noncoding RNA):
Cancer Cell 2014; PMC4159613
Cancer Cell 2015; PMC4777353
Nat Struct Mol Biol 2016; PMC4927085
Cancer Cell 2018; PMC6348897
References for project 2 (tumor immunology):
New England Journal of Medicine 2003; DOI: 10.1056/NEJMoa020177
Nature 2011; DOI: 10.1038/nature10169
Nature Cancer 2021; PMC9940627
References for project 3 (targeted therapy):
Science Translational Medicine 2017; PMC5705017
Nature Communications 2019; PMC6374416
Cell Reports 2020; PMC7391471
Cell Reports 2022; PMC8919705
Candidates applying for the postdoctoral positions must hold a Ph.D. degree and have less than three years of postdoctoral experience in a related field. The compensation and health insurance for postdocs will be covered by NIH grants. A competitive salary and benefits package will be provided (~$66,000 plus postdoc benefit package). We are committed to offering our postdocs highly competitive compensation, ensuring their financial well-being, and recognizing the value of their contributions to our research community. For the PhD student positions, we seek individuals with prior research experience in biology or medical fields. Successful student candidates will receive compensation and have their tuition fees covered through a scholarship.
Please forward your application materials, including the cover letter, c.v., publication list, and referee email addresses, to：
Lin Zhang MD, Harry Fields Research Professor
Institute for Translational Medicine and Therapeutics
Center on Research for Reproduction and Women’s Health
Abramson Cancer Center
Department of Obstetrics and Gynecology
University of Pennsylvania School of Medicine
Email: linzhang@pennmedicine.upenn.edu
About the University
The University of Pennsylvania, a globally recognized institution, stands at the forefront of education, research, and innovation. As an esteemed Ivy League university, Penn consistently ranks among the top 10 universities in the prestigious U.S. News & World Report survey. With its rich history and tradition, Penn is home to 12 renowned schools that offer diverse opportunities for undergraduate, graduate, and continuing education. What sets Penn apart is its distinctive interdisciplinary approach to scholarship and learning, fostering a vibrant academic environment.
Situated in the heart of Philadelphia, Penn provides a unique working environment. Its urban campus combines the beauty of a traditional campus with the dynamic energy of a major city. Within close proximity, a plethora of educational, cultural, and recreational activities await, catering to diverse interests and passions. Philadelphia itself boasts historical significance and landmarks, offering a captivating backdrop for both work and play.
With its thriving arts scene, world-class museums, diverse culinary offerings, and vibrant neighborhoods, Philadelphia presents an exceptional quality of life for students, faculty, and staff. Whether exploring the city's historic sites, attending cultural events, or enjoying outdoor recreational spaces, Philadelphia offers a stimulating and enriching experience for all.
Choosing the University of Pennsylvania means embracing a top-tier educational institution within a city that epitomizes opportunity, creativity, and exploration. It is a place where academic excellence meets cultural richness, making it an ideal home for both professional and personal growth.
About the School
Penn Medicine is a renowned academic medical center globally recognized for its commitment to medical education, groundbreaking biomedical research, and the delivery of exceptional patient care. The enterprise encompasses the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania, established in 1765 as the first medical school in the United States, as well as the University of Pennsylvania Health System. Together, these entities form an impressive $8.6 billion enterprise.
For over two decades, the Perelman School of Medicine has consistently ranked among the top medical schools in the United States, as acknowledged by U.S. News & World Report's survey of research-oriented medical schools. The School continuously receives substantial funding from the National Institutes of Health, making it one of the nation's leading recipients. In the fiscal year of 2019, the School was awarded $494 million in NIH funding.
Penn Medicine's patient care facilities include the highly acclaimed Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center, both recognized as top "Honor Roll" hospitals by U.S. News & World Report. The health system also comprises Chester County Hospital, Lancaster General Health, Penn Medicine Princeton Health, and Pennsylvania Hospital—the first hospital in the nation, established in 1751. Additionally, Penn Medicine operates several other facilities and enterprises, such as Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.
Employing a workforce of more than 43,900 dedicated individuals, Penn Medicine thrives on the talent and commitment of its exceptional staff. The organization has forged strategic alliances with esteemed community health systems in Southeastern Pennsylvania and Southern New Jersey, providing expanded options for patients, regardless of their geographical location.
Penn Medicine demonstrates its unwavering dedication to enhancing lives and promoting health through an array of community-based programs and initiatives. In fiscal year 2019 alone, Penn Medicine contributed over $583 million to benefit the community it serves.
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